Which is starting material for synthesis of Sulphanilamide?

Which is starting material for synthesis of Sulphanilamide?

Principle: Sulphanilamide can beprepared by taking acetanilide and treating it with excess of chlorosulphonic acid, which gives p-acetamidobenzenesulphonyl chloride which readily converted into corresponding p-acetamidobenzenesulphonamides upon reaction with ammonia or ammonium carbonate.

When acetanilide and Chlorosulphonic acid gets react in the synthesis of Sulphanilamide it form?

This is the first step of the processes where required amount of acetanilide is reacted with chlorosulfonic acid to obtain an intermediate called p-acetamidobenzenesulfonyl chloride. This mixture is made to react in a reflux condenser for about 15-20 min where a semisolid paste is obtained which is brown.

Which catalyst is used for synthesis of sulfanilamide?

The reaction between sulfonyl halide and amines is usually catalyzed by basic catalyst such as sodium carbonate, potassium carbonate, pyridine or triethyl amine. The sulfonyl chloride method represents the most simple and direct route for the preparation of sulfonamides.

What is the starting material for synthesis of P Acetamidobenzene sulfonyl chloride?

The invention takes acetanilide and chlorosulfonic acid as raw materials, uses phosphorus pentachloride as chlorinating agent; under the action of organic dissolvent, the raw materials are sulfonated, chloridized, separated, and washed to obtain the product.

How many steps are involved in synthesis of sulfanilamide from Acetanilide?

Preparation of sulfanilamide from three steps: 1″Chlorosulfonation of acetanilide.” 2″Amination of p-chlorobenzene sulfonyl chloride.” sulfanilamide.”

What is the functional group of Acetanilide?

amide functional group
Acetanilide has an amide functional group, meaning it has a nitrogen atom bonded directly to a carbonyl (carbon-oxygen double bond). Acetanilide can be described by two resonance structures, with the one that places a positive charge on the nitrogen atom helping to explain why it is non-basic.

What health concern is associated with aniline impurities in Acetanilide?

A Health Concern of Acetanilide The problem with aniline being present as an impurity is that aniline is a carcinogen (cancer-causing agent). So although your headache may get better, you run the risk of contaminating yourself with a cancer-causing compound, which is of much greater concern.

What is the role of zinc dust in preparation of acetanilide from aniline?

What is the need to add zinc during the preparation of acetanilide? Zinc is added to prevent the oxidation of aniline during the reaction. It reduces the coloured impurities present in the solution.

Why aniline is more reactive than acetanilide in electrophilic substitution?

Acetanilide is less reactive towards the electrophilic substitution than Aniline, as it donates electrons to the benzene ring and to the positively polarized carbonyl group, whereas Aniline donates electrons only to the benzene ring.

How is acetanilide prepared from aniline?

Acetanilide is prepared from aniline when it reacts with acetic anhydride/glacial acetic acid in the presence of zinc dust. A mixture of aniline, glacial acetic acid, acetic anhydride and zinc dust is refluxed under anhydrous condition and then poured the mixture into ice cold water to get acetic anhydride precipitate.

Why is acetanilide not used as a painkiller anymore?

In the body acetanilide is mostly converted to acetaminophen, which has replaced acetanilide in therapy because it is less likely to induce blood disorders.