Table of Contents
- 1 What is the significance of toxicological findings?
- 2 How can insects recovered from a decomposing body help with toxicological analysis?
- 3 What is the most useful and best sample for toxicological analysis in cases involving decomposed or exhumed bodies?
- 4 What is the importance of skin toxicity testing?
What is the significance of toxicological findings?
As such, toxicological analysis represents a tool for assessing the degree of impairment exerted by a drug or combination of drugs. With the ultimate degree of impairment being death, toxicological findings are also used to determine cause and manner of death.
What is the most useful in the best sample for toxicological analysis?
The best specimen for comprehensive drug and poison screening is urine (3). The accumulation of drugs, poisons, and metabolites in urine will often result in high concentrations that facilitate their detection. A minimum of a 30- ml sample of urine is required for thorough screening of this specimen (4).
What are the three main objectives to toxicological investigations?
The three primary concerns of forensic toxicology investigations include determining whether or not a harmful substance could cause death, impair judgment, and change behavior, or has a legitimate presence in the body.
How can insects recovered from a decomposing body help with toxicological analysis?
In forensic entomology using the insects on the carcass, we can find various factors such as time of death, climatic condition, death location and presence of drugs or toxins in the body (1, 2). There is a correlation between drug concentration in substrate and bred insects’ development on the substrate.
What are the main objectives of toxicological examination?
toxicological examination, medical inspection of an individual who is, or is suspected of being, poisoned. In most poisoning cases, the toxic agent is known, and the physician’s main concern is to determine the degree of exposure.
What can we learn from a toxicology report?
How do the toxicology reports help determine cause of death? Experts look to see if the concentration of drugs or poisons are in the toxic or lethal range, Magnani says. They take into account other information, such as symptoms before their death.
What is the most useful and best sample for toxicological analysis in cases involving decomposed or exhumed bodies?
Arterial or venous femoral and cardiac blood, urine, vitreous humour, gastric content and organs (namely the liver and lungs and always after evisceration) are the most important samples to be collected [2,3].
What are the methods used in the toxicological analysis?
Forensic toxicology laboratories use a variety of different techniques, including gas and liquid chromatography, mass spectrometry, spectrophotometry, and antibody-based immunoassays. Qualitative and quantitative methods of analysis are used to determine which drugs or poisons are present, and at what concentration.
Which substance is the most important for toxicological analysis?
Blood has been used as the primary sample for forensic toxicological analysis following death of any person. Several studies used blood for determining a number of compounds for forensic analysis.
What is the importance of skin toxicity testing?
In the assessment and evaluation of the toxic characteristics of a substance, determination of acute dermal toxicity is useful where exposure by the dermal route is likely. It provides information on health hazards likely to arise from a short-term exposure by the dermal route.